A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Cell line development plays a pivotal role in the manufacturing of therapeutic proteins, vaccines and other biologics.

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

The second tool is the CRISPR-Cas9 system, which allows easy and precise editing of any region of the genome. When it comes to traditional immortalized cell lines, such as HeLa or HEK293, cutting with ...

In the study, the investigators used metabolomics and CRISPR-Cas9 genome editing to target and inhibit pyrimidine synthesis ...

CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells. Verma N, Zhu Z, Huangfu D. Methods Mol Biol. 2017;1513:119-140. PMID:27807834 CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem ...

Editas and CRISPR are probably most closely linked as they both pursued Sickle Cell Disease (SCD ... Even with the only approved CAS9 based treatment out there, CRISPR is still years away from ...

With the addition of Casgevy, Children’s Hospital Los Angeles now offers two gene therapies for sickle cell, the first being Lyfgenia.