In silico activities are displayed in orange, biophysical screening activities are displayed ... within the BRPF1b active site (grey cartoon, PDB = 6EQK). Key residues are represented in grey ...

Recent advances in biophysical screening technology have made the detection of binding events associated with the smallest of fragments possible. Often the biological target of interest has been ...

Biophysical methods are used extensively in hit finding (fragment-based screening and high-throughput screening), hit validation, in depth characterization of compound binding and lead optimization.