The Berkeley mouse model of SCD was created in 1997 and the Townes model in 2006. Both have been widely used in sickle cell research. When they searched the literature, Weiss and Woodard found little ...

Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to ...

Surprisingly, 70% of the Berkeley mice died from the therapy and it only activated production of the healing fetal hemoglobin gene in 3.1% of mouse's stem cells.