Physiological Roles of Autophagy How much and what parts of the cell can be eaten without causing cell death? Scientists hypothesized that the level of autophagy and the cargo specificity must be ...

promotes cell death. Although experimental evidence to support this is currently lacking, insight into the role of autophagy in tumour suppression is beginning to evolve. How defective autophagy ...

However, when cells experience oxidative stress, H 2 O 2 levels can lead to autophagic failure and eventually cell death. But how? To get an answer to that and understand how autophagy can go ...

These disruptions ultimately resulted in Purkinje cell death and motor gait dysfunction, underscoring the critical role of ...

Similarly, autophagy, a mechanism for cellular self ... Ferroptosis, a form of iron-dependent cell death, has been identified as a promising target in triple-negative breast cancer (TNBC).

Indeed, recent research indicates that there are other forms of programmed cell death, including an intracellular degradation process known as autophagy, which we found SAHA can trigger. Currently, we ...

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

The study, published in EMBO Molecular Medicine, shows that a process called chaperone-mediated autophagy (CMA ... of the underlying causes of cancer cell spread. "Our hope is that the new ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As ...