Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ...

4 “From there, the idea was, first, looking in another mouse model,” Salazar said. “And also trying to unravel a little bit of the cellular mechanisms that were at play here.” To model ataxia, the ...

Finally, the researchers investigated whether silencing LINE-1 elements would improve mice’s ataxia. To stop LINE-1 jumping, they gave 4-week-old model mice 3TC, an FDA-approved antiretroviral drug ...

Production of clinically recognizable disease only in suckling mice (commonly observed signs: oily hair, jaundice, peritoneal exudate, ataxia; a ‘neurotropic’ variant killed infant mice ...

In mice lacking Scn1b, a condition resembling DEE52 develops, characterized by spontaneous whole-body seizures, failure to thrive, ataxia, and cardiac arrhythmias. These symptoms lead to premature ...

The scientists then administered the connector to model mice treated to develop Alzheimer’s disease, cerebellar ataxia and spinal cord injury, and discovered that they recovered from the ...