Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...

A targeted therapy developed by scientists at University of Utah Health slows the progression of a condition in mice that mimics a rare disease called ataxia. In a parallel collaborative study, led by ...

Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological ...

Other measures of ataxia also force the animal to move, including the balance beam, which scores hind paw slips from the beam as mice traverse it 2. Some animals stop moving during this test ...

In their study, published in Nature, the team engineered mice to carry the ataxin-2 gene, which causes ataxia in humans, according to a statement. They then injected the animals with antisense ...

Mouse models treated with the sleep aid lemborexant had less brain damage compared to controls and mice that received a ...

More information: Chih-Chun Lin et al, Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm ...

To model ataxia, the team selectively silenced Purkinje cells in mice, which caused ataxia-like motor impairments. 5 “We're using possibly what I think is one of the cleanest ataxia models that is ...

Mice with Kcnj10 deletions became dehydrated, with definitive evidence of renal salt wasting. Mutations in KCNJ10 cause a specific disorder, consisting of epilepsy, ataxia, sensorineural deafness ...

Well-timed exercise programs may slow the progression of Friedreich's ataxia, which robs patients of their ability to walk, new research suggests. A top exercise researcher at the University of ...