A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...

Discover how the ALA-CART platform enhances CAR T cell efficacy against antigen-low leukemias. With improved LAT activation, ...

T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of ... potential for immunogenicity of synthetic receptors requires analysis of all foreign ...

A patient has achieved over 18 years of remission from neuroblastoma, a type of nerve cell cancer, following treatment with chimeric antigen receptor (CAR) T cell therapy and without requiring any ...

The research team hypothesized that binding of the antigen to the T-cell receptor would cause a conformational change, allowing it to initiate a downstream signaling cascade. By comparing an ...

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of ...

The TCR increases the number and types of proteins available to surveilling T cells. Unlike a CAR, which only detects antigens expressed on the surface of a cell, a TCR can also access the ...

UK-based Enara said the funds will be used to develop its pipeline of T cell receptor (TCR)-based therapies ... can therefore present novel peptide antigens on their surface, coded by these ...

GPA33 antigen (colorectal cancer); GD2 antigen (neuroblastoma); and the HER2/neu receptor (breast cancer). Illustration of three-step DOTA-PRIT based on targeting with an IgG-scFv bispecific antibody ...