Preview the May 4 matchup between the Pittsburgh Pirates and San Diego Padres with odds over/under, game spread, betting lines and more.

Aside from a rough abbreviated outing vs. the Yankees in early April, Mitch Keller has enjoyed a largely solid beginning to the season, producing four quality starts in his other five appearances.

Luis Arraez had three run-scoring hits to lead the San Diego Padres to a 9-4 win over the host Pittsburgh Pirates on Friday ...

The Pittsburgh Pirates hung around for a while but fell 9-4 to the San Diego Padres in the opening game of a series on Friday night. Adam Frazier homered to bring the Pirates within a run in the sixth ...

PITTSBURGH — Stephen Kolek pitched 5 2/3 scoreless innings in his first major league start and combined with four relievers for the San Diego Padres ... but Adam Frazier struck out and ...

Stephen Kolek pitched 5 2/3 scoreless innings in his first major league start and combined with four relievers for the San ... Adam Frazier struck out and Hayes was picked off at second base ...

The Padres scored early and late and otherwise rode their excellent pitching staff to a 5-1 victory in Wednesday’s series ...

Stephen Kolek pitched 5 2/3 scoreless innings in his first major league start and combined with four relievers for the San ...

(AP Photo/Gene J. Puskar) Pittsburgh Pirates manager Derek Shelton stands in the dugout during a baseball game against the San Diego Padres in Pittsburgh, Friday, May 2, 2025. (AP Photo/Gene J. Puskar ...

Stephen Kolek pitched 5 2/3 scoreless innings in his first major league start and combined with four relievers for the San Diego Padres ... on with one out, but Adam Frazier struck out and Hayes was ...