The adeno-associated viral (AAV) vectors have not been exploited extensively partly due to inability to generate high titer helper free recombinant viruses. Furthermore, the size of the transgene ...

To overcome these barriers, researchers explored lentiviral vectors, which integrate into the genome and bypass AAV-specific limitations. In the study, "Lentiviral Gene Therapy with CD34 ...

adeno-associated virus (AAV), retrovirus, or lentivirus, or non-viral platforms, such as lipid nanoparticles, to transport the chosen plasmids, cDNA, or RNA molecules. 2 However, not all vectors have ...

AAV vectors have a low immunogenicity profile ... They can infect both dividing and non-dividing cells and provide stable, long-term gene expression. Lentiviral vectors, derived from HIV-1, are widely ...

Gene therapy represents a paradigm shift in modern medicine, offering unprecedented opportunities to combat diseases at their ...

A new vector system known as lentiviral vectors can permanently integrate the gene into dividing and non-dividing cells. The capacity of lentiviral vectors to reliably integrate at various genomic ...