To overcome these barriers, researchers explored lentiviral vectors, which integrate into the genome and bypass AAV-specific limitations. In the study, "Lentiviral Gene Therapy with CD34 ...

The adeno-associated viral (AAV) vectors have not been exploited extensively partly due to inability to generate high titer helper free recombinant viruses. Furthermore, the size of the transgene ...

adeno-associated virus (AAV), retrovirus, or lentivirus, or non-viral platforms, such as lipid nanoparticles, to transport the chosen plasmids, cDNA, or RNA molecules. 2 However, not all vectors have ...

AAV vectors have a low immunogenicity profile ... They can infect both dividing and non-dividing cells and provide stable, long-term gene expression. Lentiviral vectors, derived from HIV-1, are widely ...

A new vector system known as lentiviral vectors can permanently integrate the gene into dividing and non-dividing cells. The capacity of lentiviral vectors to reliably integrate at various genomic ...

More recently, the Vector Development Laboratory merged with our group, and we have expanded our services to offer AAV, first-generation adenovirus (FGAd), helper-dependent adenovirus (HDAd), ...