The San Francisco 49ers need a fully healthy Christian McCaffrey in 2025. Full stop. Furthermore, Kyle Shanahan needs McCaffrey on the field to unlock the full potential of the 49ers offense. But what if I told you that second-year running back Isaac Guerendo could be the key to unlocking McCaffrey’s efficiency and the full potential of the 49ers offense?

San Francisco 49ers coach Kyle Shanahan explained why he has confidence that fatherhood won’t change “psycho” Christian McCaffrey.

The San Francisco 49ers are certainly hoping Christian McCaffrey is healthy for all 17 games this NFL season. Will he be able to hold off the injury bug though? When healthy, McCaffrey is one of the best players in the NFL.

Last week, the NFL had its third week of revealing players in the "NFL Top 100." After two players were revealed on Monday and another on Tuesday the Arizona Cardinals will face in 2025, a fourth was revealed later in the week, one who will see the Cardinals twice in 2025. That would be San Francisco 49ers running back Christian McCaffrey.

49ers' Christian McCaffrey's Wife Stuns In Online Photoshoot originally appeared on Athlon Sports. San Francisco 49ers running back Christian McCaffrey is looking to bounce back from an injury-riddled 2024 season and be the dominant force we know he can be. And he'll have more motivation to do so soon.

From 2019-2023, the 49ers won 54 regular-season games -- only the Packers won more games among NFC teams -- and went to two Super Bowls, falling to the Chiefs both times. The 49ers' eight playoff wins over that span were second in the NFL, only behind Kansas City. That Patrick Mahomes guy has a way of standing in the way, doesn't he?

The Atlanta Falcons are currently gearing up for a 2025 NFL season in which they will hope to bounce back under the leadership of second year quarterback Michael Penix Jr. The Falcons also have one of the league’s most talented running backs in Bijan Robinson, who burst onto the scene in 2023 and improved even more in 2024.

Christian McCaffrey is gettng set to leave for camp as wife Olivia Culpo bidded farewell as he leaves her and their newborn.