BOTTOM LINE: The Cleveland Guardians, on a three-game home winning streak, host the Baltimore Orioles. Cleveland is 50-50 overall and 24-24 at home. The Guardians have gone 18-10 in games when they hit two or more home runs.

The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

The Guardians are now 4-1 since the All-Star break and 10-2 since their 10-game skid following a second consecutive win against the Orioles.

Angel Martínez had three hits, José Ramírez homered and the Cleveland Guardians defeated the Baltimore Orioles 6-3 Tuesday night for their fourth win in five games since the All-Star break. Kyle Manzardo and Bryan Rocchio each drove in a pair of runs as the Guardians have won 10 of 12 after a 10-game losing streak to get back to .500 at 50-50.

Every time the Orioles knocked on the door in Cleveland tonight, the Guardians answered. It resulted in the Guards taking Game 2 of this four-game series by a final score of 6-3.First half of the game didn’t go so well for us tonight and I thought we hung in there and the at-bats were good and we put up a couple runs as the game went

The Guardians started early and finished last Tuesday night, much to the chagrin of the Orioles, who could not keep pace. Three batters into the first inning, Jose Ramirez hit his 21st homer and the Guardians delivered a steady stream of offense on the way to a 6-3 win at Progressive Field.

The Guardians used a left-handed starter and stacked nine lefties and/or switch-hitters in their lineup to beat the Orioles on Tuesday.