Staffers at the US National Institutes of Health published a letter of dissent, taking issue with what they see as the politicization of research and destruction of scientific progress under the Trump administration.

On Monday, scores of scientists at the agency sent their Trump-appointed leader a letter titled the Bethesda Declaration, challenging “policies that undermine the NIH mission, waste public resources, and harm the health of Americans and people across the globe.”

Over 300 researchers from the National Institutes of Health have published a letter rebuking its director and the Trump administration for deep, politically motivated cuts to research funding, as well as disrupting global collaboration, undermining scientific review processes, and laying off critical NIH staff.