Homestead is an unincorporated community in Iowa County, Iowa, United States. Homestead is a census-designated place with the population recorded as 135 in the 2020 census. Homestead is in northeastern Iowa County at the junction of U.S. Route 151 with U.S. Route 6. US 151 leads northeast 22 miles to Cedar Rapids and west, then south 7 miles to I…Homestead is an unincorporated community in Iowa County, Iowa, United States. Homestead is a census-designated place with the population recorded as 135 in the 2020 census. Homestead is in northeastern Iowa County at the junction of U.S. Route 151 with U.S. Route 6. US 151 leads northeast 22 miles to Cedar Rapids and west, then south 7 miles to Interstate 80, while US 6 leads east 19 miles to Iowa City and west 11 miles to Marengo, the Iowa County seat. Amana is 3.5 miles north of Homestead along US 151.